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Tirzepatide options typically hit harder initially, with more patients reporting vomiting or diarrhea in early weeks, while semaglutide-based drugs tend to cause nausea that tapers off as the body adjusts
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Mainly expressed in the ileum and colon, GLP-1 is known as the most powerful incretin in humans and lowers postprandial blood glucose via augmentation of glucose-dependent insulin release from pancreatic β-cells, inhibition of glucagon secretion from pancreatic α-cells, and delay of GE
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